Cytoskeleton Regulation of Ion Channels

Cytoskeleton regulation of ion channels.

C ardiac arrhythmia is one of the leading causes of sudden death in developed countries, and results from abnormal cardiac electric activity. Regular beat-to-beat cardiac excitability requires the coordinated activity of membrane-bound ionophoric proteins that are channels and transporters. Aberrant currents can result from either changes in the gating properties of ionophores or altered traffi...

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Interaction of epithelial ion channels with the actin-based cytoskeleton.

The interaction of ion channels with the actin-based cytoskeleton in epithelial cells not only maintains the polarized expression of ion channels within specific membrane domains, it also functions in the intracellular trafficking and regulation of channel activity. Initial evidence supporting an interaction between epithelial ion channels and the actin-based cytoskeleton came from patch-clamp ...

Calcium Regulation of Ion Channels in Neurons

Intracellular calcium modulates the activity of a number of voltagedependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even determine the pattern of electrical activity of neurons. In this review, I will summarize the role...